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In molecular biology Proteinase K (also referred to as protease K or endopeptidase K) is actually a wide-spectrum serine protease. The enzyme was discovered in 1974 in extracts from the fungus The enzyme was uncovered in 1974 in extracts with the fungus Parengyodontium album (formerly called Engyodontium album or Tritirachium album).myMDAnderson